Written assignment and pressntation Example | Topics and Well Written Essays - 1000 words

Written and pressntation - Assignment Example Psoriasis is characterized by abnormal differentiation of the keratinocytes, epidermal hyperplasia and high concentration of neutrophils (Gudjonsson et al., 2004). Psoriasis results in proliferation and dilatation of the skin blood vessels and thereby increases the concentration of the inflammatory cells in the dermis. Many systemic disorders are found to be related to Psoriasis such as diabetes mellitus, Crohn’s disease, cardiovascular disease, cancer, obesity, depression, and metabolic syndrome. (Mak, Hundhausen & Nestle, 2010). The types of psoriasis are Plaque psoriasis, Flexural Psoriasis, Seborrheic psoriasis, Guttate psoriasis, Postilar psoriasis, non-Postular Palmar Plantar psoriasis, and Nail psoriasis. The most common form of psoriasis is the plaque psoriasis which accounts for 90% of the cases (Roberson & Bowcock, 2010). As psoriasis is characterized by the keratinocyte concentration, a variation in the maturation and production of these keratinocytes leads to the i ncreased inflammation and promotes angiogenesis (Quesniaux, Ryffel & Pavoda, 2009). Psoriasis was initially considered as an autoimmune disease mediated by Th 1 Lymphocytes but the recent studies have found that IL- 23, IL- 22 and Th 17 are the important mediators of the disease (Gudjonsson et al., 2004). IL -22 was found to be at high concentration in the psoriasis patients whereas in the healthy persons, the molecule was not detectable. The treatment with Cyclosporin A has reduced the IL- 17 and IL 22 gene expression in the psoriasis patients (Gudjonsson et al., 2004). The inflammatory nature of the skin clearly proves that the immune cells react with an unidentified antigen in the body. Genome wide linkage studies were performed, to identify the key factor in the chromosomes. It was found that human leukocyte antigens (HLA) have a significant association with psoriasis. HLA A, HLA B and HLA C linkage to psoriasis was confirmed

The Role of Play Essay Example | Topics and Well Written Essays - 500 words

The Role of Play - Essay Example The relaxation hypothesis points out that play is a means of recuperating from tiredness and hard labor, while the practice hypothesis pronounces play as a fundamental activity (Isbell & Raines, 2013). Within modern suppositions of psychoanalytic movement, theorists concentrated on emotional development characteristics whereby pleasure is accomplished through fulfillment of wishes within play. These individuals believed that kids came up with cooperative affiliations and gain reciprocated trust. The constructivist hypothesis views play as a means by which kids learn to comprehend experiences. The sociocultural theory looks into the sociocultural and chronological forces, which impacts the kid’s cognitive development. Cognitive adaptation theorists believe that play is a means to promote cognitive adaptation (Isbell & Raines, 2013). Hypothesis of mind articulates that pretend play utilizes mental demonstration, and role-play as a means of comprehending others. Experience and prospects throughout play are indispensible to neural pathways and learning development since play offers the framework for experiences. Play is important because it is the principal vehicle for the development of conceptions and solving of predicaments. Within curriculums, play aids in learning, societal, motor skill, emotional, scholarly, and language development. The modern conception of playfulness concentrates on the internal disposition of being playful. Kids go through sensory exploration, egocentric speculation, and individual experimentation to gain playfulness and resourcefulness (Isbell & Raines, 2013). Societal play takes in kids’ capacity to interrelate with peers. Socio-dramatic play takes account of at least 2 kids who interrelate verbally and collaborate within their activity, regulating their functions in rejoinder to other kids. The play environ is quite multifaceted and is made up of physical, as well as societal